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SkinCeuticals A.G.E. Interrupter Advanced

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A.G.E. Interrupter Advanced is a potent corrective cream that helps reverse visible signs of aging impacted by glycation and collagen decline, including fine lines and deep wrinkles. 

Formulated with 18% concentrated ProxylaneTM, 4.25% wild fruit flavonoid blend of blueberry and pomegranate extracts*, and 0.1% glycyrrhetinic acid, this breakthrough anti-aging cream is clinically proven to help smooth visible lines and wrinkles in five facial zones targeted for aesthetic procedures. 

*Due to the high concentration of naturally derived flavonoids, this cream's color may vary but results will remain constant.

SKIN TYPES: Dry, Normal, Combination, Sensitive



Glycation is a key factor of natural aging. During this multi-phase process, excess sugars bind to the structural proteins that are responsible for skin’s smooth and supple appearance, such as collagen and elastin. When this occurs, damaging byproducts known as advanced glycation end-products (A.G.E.s) are formed. A.G.E.s cause collagen and elastin to become weak and brittle, leading to visible signs of aging including wrinkles, loss of firmness, and dullness. 

Externally, visible signs of collagen glycation typically appear by age 35. Internally, however, glycated collagen may first be seen as early as age 201. 

A.G.E. Interrupter Advanced goes beyond traditional anti-aging products, helping to correct existing signs of aging and defend against new and recurring damage caused by A.G.E. formation.  


Key Benefits:

  • Helps address the complete multi-phase glycation process, a key factor of natural aging in which excess sugar molecules bind to collagen and elastin, weakening the skin’s underlying support structure  
  • Visibly smooths fine lines and five wrinkle types, including forehead wrinkles, nasolabial folds, marionette wrinkles, glabellar wrinkles, and crow’s feet 
  • Delivers 24-hour hydration in a rich, satin texture
  • Comforts dry, aging skin 
  • Paraben-free, alcohol-free, and dye-free


After 12 weeks, A.G.E. Interrupter Advanced improved attributes associated with skin aging and glycation, including line and deep wrinkles in five facial zones.

  • 14% global fine lines
  • 11.5% forehead wrinkles
  • 11.2% nasolabial folds
  • 7.9% marionette wrinkles
  • 7.3% glabellar wrinkles
  • 7% crow’s feet

Protocol: A 12-week, single-center, clinical study was conducted on 77 females with Fitzpatrick type I-IV, ages 35-75, and mild to moderate global wrinkles, fine lines, laxity, rough skin texture, uneven skin tone, and a dull complexion. A.G.E. Interrupter Advanced was used twice daily over face, neck, and chest in conjunction with a sunscreen for 12 weeks. Efficacy and tolerance evaluations were conducted at baseline, weeks 4, 8, and 12.




Helps support skin’s integrity and correct visible signs of aging, like wrinkles and laxity.


Blend of blueberry and pomegranate extracts helps defend against glycation, including UV-induced glycation, and protect against free radical damage.


Helps counter dull tone, which can be linked to A.G.E. accumulation.


Activates natural enzymes in skin to promote even cell turnover while hydrating skin.


Water-soluble vitamin, also known as vitamin B3, soothes and helps support skin’s moisture barrier.

Aqua / Water, Hydroxypropyl Tetrahydropyrantriol, Glycerin, Propylene Glycol, Stearic Acid, Butyrospermum Parkii Butter / Shea Butter, Hydroxyethylpiperazine Ethane Sulfonic Acid, Palmitic Acid, Pentylene Glycol, Oleyl Alcohol, Arachidyl Alcohol, Myristyl Myristate, Panthenol, Niacinamide, Dimethicone, Isononyl Isononanoate, Bis-Peg/Ppg-16/16 Peg/Ppg-16/16 Dimethicone, Glyceryl Stearate, Candelilla Cera / Candelilla Wax, Behenyl Alcohol, Peg-100 Stearate, Sodium Polyacrylate, Pentaerythrityl Tetraisostearate, 4-T-Butylcyclohexanol, Arachidyl Glucoside, Caprylyl Glycol, Xanthan Gum, Chlorphenesin, Myristic Acid, Caprylic/Capric Triglyceride, Glycyrrhetinic Acid, Parfum / Fragrance, Sorbitol, Vaccinium Myrtillus Fruit Extract, Potassium Hydroxide, Adenosine, Citric Acid, Punica Granatum Fruit Extract, Limonene, Coumarin, Linalool, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate